A hybrid scheme which uses both feature-based and intensity-based methods is proposed.In particular,an edge-based image registration approach is developed to guide the intensity-based registration which uses optical flow estimation.The idea of coarse-to-fine multi-scale iterative refinement is also utilized.The combination of these different methods tends to compensate for any deficiencies in the individual methods.Experiments show that our approach provides accurate registrations for the multi-spectral images application.