Selection of small molecules targeting Dclk1 of tumor stem cellsby phage display and computer aided

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：voidemort

【摘要】

：

【作者】

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Yijie Zhou Bowen Tan Yinsong Dong Canquan Mao

【机构】

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Southwest Jiaotong University

【出处】

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

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2014年3期

【关键词】

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Dclk1 peptide inhibitors virtual screening bioinformatic phage display

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Targeted therapy is a promising way for cancer based drug development.Among variouscancer associated targets, tumor stem cells (TSCs) hold great potential as recent discoveryof their important role in cancer development and resistant to therapy.Doublecortin-likekinasel (Dclkl) is a serine-threonine kinase which has been found as a marker in tumorstem cells.

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Selection of small molecules targeting Dclk1 of tumor stem cellsby phage display and computer aided

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