The protective effects of metallothionein-Ⅰ/Ⅱ against cerebral ischemia and reperfusion injury

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：mfxtmxk

【摘要】

：

【作者】

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Min FENG Chang HUANG Jia-bin GUO Mu LI Jun ZHAO Shuang-qing PENG

【机构】

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Evaluation and Research Centre for Toxicology, Beijing Institute of Disease Control and Prevention,

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

：

metallothionein cerebral ischemia reperfusion astrocytes oxygen glucose deprivat

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Aim: Metallothioneins are ubiquitous low molecular weight, cysteine-rich and metal binding proteins in mammals.The major isoforms in CNS are MT-Ⅰ and-Ⅱ which localize mainly in astrocytes.Recently significant efforts have been made to the study the biological functions of MT-Ⅰ/Ⅱ in the central nervous system.This study is to investigate the role of MT-Ⅰ/Ⅱ in cerebral ischemia reperfusion injury in focal ischemia repeffusion model and oxygen-glucose deprivation reperfusion model.

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The protective effects of metallothionein-Ⅰ/Ⅱ against cerebral ischemia and reperfusion injury

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