During past decades,the concept of microfluidic chemistry received increasing attention and attempts to develop environmentally benign chemical processes were intensified.The new conceptual devices must enhance their intrinsic advantages to perform any smarter and greener process.In here,we present various automated total processes for the generation of the toxic and carcinogenic reagents,its purification,its utilization for a desired synthesis followed by quenching of the unused,which are conducting in a micro-total envelope system(μ-TES)with no exposure to the harmful or the unstable chemicals.