The goals of health hazard assessment for industrial chemicals typically involve gaining enough information to provide a hazard classification according to a classification system such as the Globally Harmonized System of Classification (GHS) as well as derivation of the most sensitive endpoint and concentration-effect level for health risk assessment.Hazard Classification under the GHS scheme involves animal testing of several endpoints that typically are not used for risk assessment, but may provide information for the design of higher tier testing that can be used to identify the most sensitive and appropriate endpoint for human health risk assessment.The goal of this presentation is to review the current approach to hazard evaluation and provide examples of assessments where using a tiered testing scheme could lead to a more targeted approach that may involve the use of fewer animals and provide more accurate health hazard information for risk assessment.Specifically, this approach would use a combination of screening and standard OECD guidelines to allow the toxicologist to better determine and target endpoints for evaluation in longer-term studies.