【摘 要】
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Background: In this prospective,randomized,double-blind study,we verified the hypothesis that TEAS can alleviate remifentanil induced hyperalgesia in patien
【机 构】
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Department of Anesthesiology,Fujian Provincial Hospital & The Shengli Clinical College of Fujian Med
【出 处】
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中国中西医结合麻醉学会年会暨第二届全国中西医结合麻醉学术研讨会
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Background: In this prospective,randomized,double-blind study,we verified the hypothesis that TEAS can alleviate remifentanil induced hyperalgesia in patients undergoing thyroidectomy.Methods: 60American Society of Anesthesiologists physical status(ASA)Ⅰ-Ⅱpatients,aged 18-60 year,scheduled for thyroidectomy were randomly allocated to TEAS or control groups.TEAS consisted of 30 min of stimulation(6-9mA,2/10Hz)on the Hegu(LI4)and Neiguan(PC6)before anaesthesia.Anesthesia was maintained with sevoflurane adjusted to bispectral index(40-60)and target remifentanil 5.0 ng/ml.Mechanical pain thresholds were assessed using electronic von Frey.The primary outcome was mechanical pain thresholds.Secondary outcomes included postoperative pain scores,the time to first rescue analgesic,additional analgesics and side effects.Results: Baseline mechanical pain thresholds were similar between two groups.The analysis revealed the reduction in mechanical threshold was greater in the control group than the TEAS group(P<0.001).Postoperative pain scores and cumulative number of rescue analgesia were lower in the TEAS group(P<0.05).In addition,TEAS group patients reduced the incidence of postoperative nausea,vomiting and shivering.Conclusion:Preoperative TEAS can attenuate remifentanil-induced hyperalgesia in patients undergoing thyroidectomy.
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