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Lymphoma is the most common hematological malignancy, and B-cell lymphoma accounts for 85％ of all lymphomas.In the United States, there are ～700,000 lymphoma patients currently living with this disease,～80,000 new lymphoma cases were diagnosed in 2014, and ～20,000 lymphoma-related deaths occur annually.M.D.Anderson is the largest B-cell lymphoma referral center in the world, but the challenge that we face is not just large in number.