A novel drug deliver method which called microneedles(MNs)has been widely focused.Compared to traditional delivery systems such as dressing and in-situ injection,microneedles has higher efficiency of drug delivery than dressing and is less pain than in-situ injection.Microneedles can pierce through stratum corneum and has limited penetration depth to stimulate nerves,so it is painless.Base on the above advantages of MNs,we used carboxymethyl cellulose(CMC)which has been approved by Food and Drug Administration(FDA)to fabricate dissolvable microneedles with minoxidil encapsulated.Minoxidil is widely used to treat androgenic alopecia which is a common disease happening to male adult at the middle ages.With the decreasing age of alopecia patients in recent years,androgenic alopecia has attracted more attention.Minoxidil has been proven as having powerful effect on stimulating hair growing.The treatment was suggested to include a concentration of 5 wt%for men,and a concentration of 2 wt%for women.However,the current method of minoxidil drug delivery has low efficiency thus limited hair regrowth.To address the present problem,we design a dissolving CMC-MNs patch to encapsulate minioxidil.The mechanical strength of MNs will be enhanced to penetrate stratum corneum and the drug release of minioxidil through MNs will be tested.In this study,we expect to improve the drug uptake through skin and develop a potential commodity for androgenic alopecia patients.