TFDP3 regulates DNA damage response under the effects of extracellular deleterious factors through binding with E2F 1 to modulate expression of downstream signaling molecules, including but not limite
Background: Gab2 (Grb2-associated binder 2), a key member of the Gab family of scaffolding adapters, serves as a critical signal amplifier downstream of various growth factor receptors.
Objective: Protein kinase C (PRKC) is a family of serine/threonine kinases, and these PRKC isozymes have crucial roles in diverse cellular signaling processes including cellular proliferation, differe
Anisomycin, an antibiotic produced by Streptomyces, strongly induces apoptosis in different histological sorts of cancer cells in vitro, superior dramatically to adriamycin.
Transforming growth factor-beta (TGF-β) suppresses T cell function to promote tumor immune escape.The essential roles of B7-H3 and B7-H4 have been uncovered in inhibiting T cell function during anti-t
Background: The Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) has been reported to have both tumor-promoting and tumor-suppressing roles in tumorigenesis and tumor development.