【摘 要】
：
The existence of high abundance proteins in human plasma severely impedes the detection of low abundance proteins.This is one of the most difficult problems
【机 构】
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The Department of Chemistry and Institute of Biomedical Sciences, Fudan University
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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The existence of high abundance proteins in human plasma severely impedes the detection of low abundance proteins.This is one of the most difficult problems encountered in plasma proteomic research.We have developed a two-dimensional liquid chromatography system with strong anion exchange chromatography and reversed-phase liquid chromatography (SAX-RPLC) for the extensive separation of plasma proteins and selective depletion of high abundance proteins.TSKgel SuperQ-5PW was selected as the first dimensional separation column for crude human plasma fractionation.Jupiter C4 column was selected as the second dimensional separation column.
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