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Circulating tumor cells (CTCs) were considered to be preconditions for the metastasis and recurrence of cancer.We hypothesized that adhesion of CTCs to vascular endothelial bed might be a crucial starting point in metastatic cascade.In the present work,we used monoclonal antibody (aEpCAM)-modified mesoporous silica nanoparticles (MSN) loaded with mifepriston (MIF) to serve as a cancer metastatic preventive nanomedicine (aEpCAM-MIF-MSN) that can interrupt adhesion and invasion of CTCs to the intima of microvasculature.