• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Genome mining of enediyne natural products as antibody-drug conjugate payload candidates

Genome mining of enediyne natural products as antibody-drug conjugate payload candidates

来源 :上海浦东免疫化学国际生物论坛 | 被引量 : 0次 | 上传用户：dsgver5r33
【摘 要】
：
Inspired by the recent success of two ADCs (Adcetris(R) in 2011 and Kadcyla(R) in 2013), virtually every major pharmaceutical company with an oncology program n
【作 者】
：
Ben Shen 
【机 构】
：
DepartmentofChemistry,DepartmentofMolecularTherapeutics,andNaturalProductsLibraryInitiative,TheScrip
【出 处】
：
上海浦东免疫化学国际生物论坛
【发表日期】
：
2015年11期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Inspired by the recent success of two ADCs (Adcetris(R) in 2011 and Kadcyla(R) in 2013), virtually every major pharmaceutical company with an oncology program now has an initiative on ADCs.Among the 60+ ADCs currently in development, however, nearly 50 of them use the same variants of auristatin and maytansine, the two payloads used in Adcetris(R) and Kadcyla(R), respectively.
其他文献
Intracellular Immunotherapy
Chromosomal translocations are cancer-specific abnormalities found in all types of human cancer ranging from leukaemias/lymphomas, sarcomas and epithelial tumou
会议
Integrative modeling of biomolecular assemblies and pathways
The networks and spatial structures of biomolecular interactions provide insights into their function and thus help us to understand the workings of living cell
会议
Post-Evolutionary Biology Design of novel protein structures, functions and assemblies
Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms.Our goal is to design a new
会议
Localizing molecules in cellular CT scans
Much like medical CT scans reveal anatomical structures in the body, soft x-ray tomography (SXT) visualizes and quantifies the organization of sub-cellular stru
会议
Chemistry and biology of glycosylation Carbohydrate-based cancer vaccine
Glycosylation in biology is ubiquitous and considered to be the most complex among the post-translational modification reactions.It is capable of affecting prot
会议
Imaging the genome in living cells
The spatial architecture and temporal dynamics of the genome play critical roles in regulating its function.However, visualizing endogenous DNA sequences in liv
会议
Membrane protein structure by single particle cryo-EM
As a versatile tool in structural biology, single particle electron cryo-microscopy (cryo-EM) has been used to determine the three-dimensional (3D) structures o
会议
Hamessing cryoEM to accelerate vaccine and immunotherapeutic development
Neutralizing antibodies are essential components of vaccine-induced protective immune responses as well as immunotherapeutics.Such antibodies, particularly agai
会议
Fever cellular and molecular mechanisms
Fever is an orchestrated body-wide stress response to different immunological and psychological stimuli.The Fever response is also our first quantitative biomar
会议
Cheating the immune system
The transmissible spongiform encephalopathies, as represented by thesheep disease scrapie,were early on recognized as being unusual in thatthey failed to elicit
会议