Studies on the Bioavailability of Arbortristoside-A in Tablet Formulations

来源 :中国上海第七届国际新药发明科技年会 | 被引量 : 0次 | 上传用户:popelrain2009
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  Nyctanthus arbortristis Linn.(Family-Oleacea) is a well documented plant.Its various parts are used traditionally folk medicine for treating various diseases.The ethanolic extract of the leaves,seeds,bark and flowers (A,B,C and D respectively) were found to have the LD50 value more than 2.0 gm,whereas of arbortristoside-A was found to be 500 mg.The extracts and arbortristoside-A are also hematologically non toxic and having significant anti-inflammatory activity.The present study has been aimed at formulation of the extracted products (A,B,C,D) and arbortristoside-A the tablet dosage forms and their bioavailability studies.The tablets were prepared by wet granulation method and subjected standard evaluation process.
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