【摘 要】
：
Increasing evidence indicates that lncRNAs play critical roles in many biological processes, but many have not been functionally characterized.Here, we repo
【机 构】
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Department of Radiation Toxicology and Oncology,Beijing Key Laboratory for Radiobiology,Beijing Inst
【出 处】
：
中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛
论文部分内容阅读
Increasing evidence indicates that lncRNAs play critical roles in many biological processes, but many have not been functionally characterized.Here, we report a novel radiation-inducible lncRNA, lnc-RI which is essential for cell survival and appropriate mitotic progression.Our data indicated that knockdown of lnc-RI resulted in spindle abnormalities and mitotic arrest simultaneously with sharply decreased mRNA and protein expression of PLK1, a key regulator of mitosis.Our data demonstrated that PLK1 is a key downstream mediator of lnc-RI in regulating mitosis, and suggested that it does so through competition between lnc-RI and PLK1 mRNA for binding to the negative PLK1 regulating miRNA, miRNA-210-p3.Furthermore, depletion of lnc-RI significantly inhibited tumor growth in nude mice.Taken together, we have identified lnc-RI as a new regulator of mitosis which acts by releasing plk1mRNA activity via competition for binding to miRNA-210-3p.
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