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  5. Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug deliver

Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug deliver

来源 :浙江省免疫学会第十次学术大会 | 被引量 : 0次 | 上传用户：nanometer
【摘 要】
：
Background: Aberrant expression of the RON receptor tyrosine kinase,a member of the MET proto-oncogene family,in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication.Here w
【作 者】
：
Liang Feng Hang-Ping Yao Yong-Qing Zhou Jianwei Zhou Ruiwen Zhang Ming-Hai Wang 
【机 构】
：
State Key Laboratory for Diagnosis & Treatment of Infectious Diseases and Collaborative Innovation C
【出 处】
：
浙江省免疫学会第十次学术大会
【发表日期】
：
2016年8期
【关键词】
：
Antibody-drug conjugate Breast cancer Lung cancer Receptor tyrosine kinase Thera 
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　　Background: Aberrant expression of the RON receptor tyrosine kinase,a member of the MET proto-oncogene family,in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication.Here we evaluated the efficacy of a novel anti-RON antibody-drug maytansinoid conjugate Zt/g4-DM1 for treatment of breast and NSCLC xenograft tumors in mouse models and explored a treatment strategy by combination of Zt/g4-DM1 with chemotherapeutics to achieve the maximal therapeutic activity.
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