【摘 要】
：
Primary sensory axons affected by dorsal root (DR) injuries fail to regenerate into the spinal cord,leading to permanent sen-sory loss.Re-entry is prevented at the dorsal root entry zone (DREZ),the CN
【机 构】
：
Department of Anatomy and Cell Biology, Shriners Hospitals Pediatric Research Center, (Center for Ne
【出 处】
：
Joint Symposium of 2016 International Neural Regeneration Sy
论文部分内容阅读
Primary sensory axons affected by dorsal root (DR) injuries fail to regenerate into the spinal cord,leading to permanent sen-sory loss.Re-entry is prevented at the dorsal root entry zone (DREZ),the CNS/PNS interface.There is no curative therapy for patients,and present approaches for overcoming this regeneration failure have had only limited success.In my lecture,I will present the comprehensive and comparative analyses that our lab has carried out,which evaluated the relative impor-tance of various neuron-extrinsic and intrinsic factors that have been considered as critical determinants of DR regeneration.I will also present evidence for a novel,largely unappreciated mechanism preventing regeneration at the DREZ.Lastly,I will describe the robust regeneration across the DREZ and further into the spinal cord that we have elicited with direct and syner-gistic targeting of neuron-intrinsic growth pathways.
其他文献
目的 探讨动脉溶栓中静脉充盈早现与溶栓并发脑出血的关系.方法 113例大脑中动脉闭塞患者接受动脉溶栓治疗，同时进行脑血管造影以判断有无静脉充盈早现，若有静脉充盈早现，则立即停止动脉溶栓，并计算静脉充盈早现及脑出血的发生率.结果 27例患者有静脉充盈早现(23％)，其中丘脑纹状体静脉充盈和脑皮质静脉充盈各为15例(13.2％)及16例(14.1％)，并发脑出血分别为9例(7.9％)及5例(4.4％)
背景 多发性硬化的炎症反应主要与Th1和Th17介导的细胞因子的上调有关，而关于NMO相关的细胞因子和趋化因子的研究则较少。目的 探讨细胞因子/趋化因子在NMO发病机制中的作用。方法 我们收集了中山大学附属第三医院住院的8例NMO患者和8例其他非炎症性神经系统患者，通过蛋白芯片测定了的102种细胞因子和34种趋化因子，比较各组细胞因子及趋化因子水平及变化趋势。
The corticospinal tract (CST) makes direct and indirect connections with spinal motoneurons,which control limb move-ment,particular skilled movements.Using Celsr3 conditional knockout mice (named as E
目的 比较青年和中年症状性脑动脉粥样硬化(cerebral artery atherosclerosis,CAA)患者危险因素和致卒中机制的异同。方法 连续入组2009年4月～2013年12月间因CAA所致缺血性卒中或短暂性缺血发作而在我院神经科住院的青年(18～44岁)和中年(45～55岁)患者。根据弥散加权成像所示急性脑梗死灶的分布模式判定CAA的致卒中机制,包括：动脉-动脉栓塞(artery
Peripheral nerve defect leads to a high disability rate.The functional reconstruction of injured nerve is an important issue in regenerative medicine.Based on the mechanisms underlying peripheral nerv
目的 调查青年缺血性卒中/短暂性缺血发作(TIA)患者的长期卒中复发风险及其预测因子。方法 前瞻性连续纳入2008年8月至2013年7月间于中山大学附属第一医院卒中中心住院的青年(18～45岁)缺血性卒中/TIA(发病2周内)患者资料，并对所有患者进行长规律随访(发病后第3、6、12个月进行随访，发病第1年后每6个月随访1次)，以调查卒中复发情况。