Integrated pharmacokinetic study of major bioactive components in dogs after oral administration of

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户：lbxs

【摘要】

：

　　Ethnopharmacological relevance: Andrographis paniculata (Burm.F.) Nees (Chuan-xin-lian) has been widely used in China, India, and other Southeast Asian coun

【作者】

：

FUShu-jun[1]XUFang-fangXu[2]WANGWen-jia[1]SHIXiao-na[1]XIAOWei[2]WANGPeng[1]

【机构】

：

Analytical Testing Center, Tianjin International Joint Academy of Biotechnology and Medicine, Tianji

【出处】

：

2015年第一届药代动力学朝阳论坛

【发表日期】

：

2015年期

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　　Ethnopharmacological relevance: Andrographis paniculata (Burm.F.) Nees (Chuan-xin-lian) has been widely used in China, India, and other Southeast Asian countries for a long time and has been effective in the treatment of the common cold, fever and diarrhea.According to the previous studies reported, a sensitive and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using multiple reaction monitoring (MRM) was developed for the simultaneous determination of andrographolide (AP), dehydroandrographolide (DP) and neoandrographolide (NP) in beagle dog plasma after oral administration of A.paniculata tablet.

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Integrated pharmacokinetic study of major bioactive components in dogs after oral administration of

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