CXCR4/CXCL12 Axis Promotes VEGF-Mediated Colorectal Cancer Angiogenesis Through PI3K/Akt and MEK/ERK

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  Chemokine CXCL12 is an extracellular chemokine which binds to its cell surface receptor CXCR4.High expressions of CXCR4 and CXCL12 are associated with biological malignant potential in colon cancers.However, the role of CXCL12 in the development of angiogenesis is not well understood.
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