【摘 要】
：
Although many extracellular axon guidance cues have been identified, the intracellular signal transduction and the cell biological mechanisms leading to directed navigation of the axon steering appara
【机 构】
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University of California, San Diego, USA
【出 处】
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中国神经科学学会第九届全国学术会议暨第五届会员代表大会
论文部分内容阅读
Although many extracellular axon guidance cues have been identified, the intracellular signal transduction and the cell biological mechanisms leading to directed navigation of the axon steering apparatus, the growth cone, remain vaguely understood.Wnt family morphogens, presented in concentration gradients along the main body axes, are now well-accepted axon guidance cues, conserved from mammals to C elegans.They signal through the Frizzled receptors to mediate axon attraction and repulsion.One of the Wnt-Frizzled signaling pathways is the highly conserved planar cell polarity (PCP) pathway, which establishes polarized cellular morphology along the plane of many different types of epithelial tissues in both vertebrates and invertebrates.We found the core PCP components are required for Wnt5a-stimulated outgrowth and anterior-posterior guidance of commissural axons in the spinal cord.Dishevelledl can inhibit PCP signaling by increasing hyperphosphorylation of Frizzled3 and preventing its internalization.Vangl2 antagonizes that by reducing Frizzled3 phosphorylation and promotes internalization.
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