Intratympanic Administration of Edaravone and Lipoic Acid for Inner Ear Protection after Noise Expos

来源 :The 4th East Asian Symposium on Otology(第四届东亚耳科研讨会) | 被引量 : 0次 | 上传用户:jiu_yue9
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Objective: To investigate the protective effects of antioxidant substances, edaravone, lipoic acid and the slow release dosage form-edaravone solid lipid nanoparticles (SLN), in steady noise-exposured guinea pigs.Design: SLN loaded with edaravone were produced by ultrasound technique.Edaravone solution or edaravone SLN were administered by intratympanic or intravenous injection after the first day of noise exposure.110 dB SPL noise centered at 0.25-4.0 kHz, exposured 4 day, 2 hours a day.After noise exposure, guinea pigs were measured ABR threshold,detected reactive oxygen species (ROS) in cochlea with electron spin resonance(ESR) and counted hair cells with argent nitrate(AgNO3) staining on 1 day, 4 day and 6 day.
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