【摘 要】
：
Siah proteins,the mammalian homologs of fly seven-in-absentia protein,have been implicated as tumor suppressors that may have pro-apoptotic activity.Althoug
【机 构】
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CenterforNeurobiologyandBehavior,ColumbiaUniversity,USA
【出 处】
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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
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Siah proteins,the mammalian homologs of fly seven-in-absentia protein,have been implicated as tumor suppressors that may have pro-apoptotic activity.Although most prior work has focused on SiaH E3 ligase activity and potential substrates,the mechanisms by which Siah induces apoptotic death have not been clear.In our study,we identify SIAH1 as a binding partner for POSH,a scaffold protein that we previously showed to be involved in apoptotic activation of the JNK pathway (EMBO J; Xu et al.,2003).We show that SIAH1 promotes cell death by activating the JNK pathway and the E3 ligase activity of SIAH1 is essential for SIAHl-evoked death.
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