【摘 要】
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Hydrogen sulfide (H2S) is now recognized as a gasotransmitter that may be involved in the pathology of Alzheimers disease (AD).The majority of amyloid precursor protein (APP) is associated with mitoch
【机 构】
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Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 40
【出 处】
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2015全国老年痴呆与认知障碍相关疾病学术大会
论文部分内容阅读
Hydrogen sulfide (H2S) is now recognized as a gasotransmitter that may be involved in the pathology of Alzheimers disease (AD).The majority of amyloid precursor protein (APP) is associated with mitochondria and acts a substrate for mitochondrial γ-secretase.Mitochondria-associated APP metabolism locally generated the proteins APP intracellular domain (AICD) and Aβ, and it may contribute to mitochondrial dysfunction in AD.
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