Pretreatment of folic acid attenuates behavioral abnormalities in an autistic rat model via methylat

来源 :The 18th Congress of the International Federation of Associa | 被引量 : 0次 | 上传用户：wb95879981

【摘要】

：

【作者】

：

Zhongping Wang Wei He Wenxue Fu Yong Zhao Zhongjun Qin Xiaoqin Xiong

【机构】

：

Department of physiology and pathophysiology, Jiujiang University, Jiujiang 332000, China

【出处】

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The 18th Congress of the International Federation of Associa

【发表日期】

：

2014年8期

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Prenatally valproate-exposed rats, which exhibit autism-like phenotypic behaviors, are used as autistic animal model.Valproate-induced aberrant demethylation on specific Wnt/β-catenin pathway genes is proposed to be the underlying mechanism that maternal valproate administration during pregnancy induces autism-like phenotypes in the offspring.

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Pretreatment of folic acid attenuates behavioral abnormalities in an autistic rat model via methylat

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