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We investigated the effect of cilostazol in phenylephrine(Phe)-induced pre-contracted aortic rings.Cilostazol induced vasorelaxation in a concentration-dependent manner.Application of the voltage-dependent K+(Kv)channel inhibitor 4-AP,the ATP-sensitive K+(KATP)channel inhibitor glibenclamide,and the inwardly rectifying K+(Kir)channel inhibitor Ba2+did not alter the vasorelaxant effect of cilostazol; however,treatment with the big-conductance Ca2+-activated K+(BKCa)channel inhibitor paxilline inhibited the vasorelaxant effect of cilostazol.