【摘 要】
：
Brain tumours remain an important cause of morbidity and mortality and affect an increasing percentage of aging adults with a crude incidence rate of 8 per 100,000 inhabitants in Europe.Diagnosis usin
【机 构】
：
MicroArt Catalonia (Europe) Spain
【出 处】
：
BIT Life Sciences 1st Annual World Cancer Congess-2008(2008中
论文部分内容阅读
Brain tumours remain an important cause of morbidity and mortality and affect an increasing percentage of aging adults with a crude incidence rate of 8 per 100,000 inhabitants in Europe.Diagnosis using Magnetic Resonance Imaging (MRI) is non-invasive, but only achieves 60-90 % accuracy, depending on the tumour type and grade.The current gold standard classification of a brain tumour by histopathological analysis of biopsy is an invasive surgical procedure and incurs a risk of 2.4-3.5% morbidity and 0.2-0.8% mortality, in addition to healtheare costs and stress to patients.There is a need to improve brain tumour classification, and to provide non-invasive methods for brain tumour diagnosis and prognosis, to aid patient management and treatment.The HealthAgents project is engaged in the development of a distributed, agent-based decision support system (DSS), which implements a series of automated classifiers based on pattern recognition methodologies for the diagnosis and prognosis of brain tumours.
其他文献
We have established a chicken model for high-throughput identification of genes directly involved in the genesis and progression of renal tumors and of solid tumors in general.The model is based on in
On the basis of its immunomodulatory and antiangiogenic properties thalidomide has undergone clinical evaluation in various malignancies, including multiple myeloma, myelodysplastic syndromes, and oth
Background: Gemcitabine (GEM) is currently used as a standard anti-cancer drug with best evidence for pancreatic cancer.Recently we discovered that glycogen synthase kinase-3beta (GSK-3beta) promotes
Presence of a substantial amount of receptor alpha (ERα) in a breast cancer sample is an index of favorable response to tamoxifen and related antiestrogens.Unfortunately, a significant proportion of s
The ultraviolet-visible absorption spectrum of camptothecin (CPT) has been been recorded in water solution at pH 5.3, where the equilibrium of the different CPT forms is shifted toward the lactonic on
Phosphatidylinositol-3-OH kinase (PI3K) signaling is crucial to the viability of many cancers and represents a selective target for therapeutic intervention.Our strategy against cancer is based on the
Introduction and Objective: Originally, BPs were developed as a drug for bone diseases, However, recent studies demonstrated that the 3rd generation nitrogen-containing bisphosphonates (BPs) induce ap
Despite compelling preclinical data, only anecdotal reports have shown that zoledronic acid (ZOMETA, Zol) exerts an anti-multiple myeloma (MM) effect in humans.We postulate that this could be related
Over the past decade, the important role of different growth factors and their receptors and signal transduction pathways in the genesis and progression of tumors has been well recognized and their me
Wide availability of systemic therapy agents has led to a considerable decline in the mortality from breast cancer.However, the biology of breast cancer remains poorly understood.Currently, highly acc