【摘 要】
：
There are two fundamental ways of combating obesity: to decrease energy intake or to increase energy expenditure.Brown adipose tissue (BAT) and beige fat are the major tissues in rodents,which functio
【机 构】
：
Institute of Molecular Medicine Peking-Tsinghua Joint Center for Life Sciences Peking University Roo
论文部分内容阅读
There are two fundamental ways of combating obesity: to decrease energy intake or to increase energy expenditure.Brown adipose tissue (BAT) and beige fat are the major tissues in rodents,which function to increase energy expenditure by stimulation of nonshivering thermogenesis.
其他文献
Oxidative stress derived from various etiologies including environmental exposure,life-style changes,and systemic inflammation,can damage pancreatic β-cells,leading to the deficiency of insulin as typ
Obesity has emerged as a major threat to public health.Essentially a disorder of energy balance,obesity occurs when energy intake exceeds expenditure.Our previous work led to the isolation of a new ty
Facing the grand challenges of biological complexity,researchers have developed the systems biologyapproaches for integrating data derived from genomics,proteomics and metabolomics and other omics,int
It remains controversial as to whether adiponectin exerts anti-or pro-thermogenic effects.Here,we show that basal,acute,and chronic cold-induced energy expenditure as well as the browning effect are e
Type 2 diabetes has become a global pandemic and imposes a growing burden to people and society.Although multiple treatment options are available,there remain unmet medical needs for better and safer
Epigenetic modifications such as histone methylation induced by "obesogenic environment" are important contributors to the sharp increase of obesity and diabetes prevalence over past 30-40 years.
Chronic exercise has beneficial effects on protecting against obesity-related metabolic dysfunction.However,the underlying molecular mechanisms are incompletely understood.
In eukaryotic cells,accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress,activating the adaptive cellular unfolded protein response (UPR).
Proteins and lipids are two major classes of transport cargos serving specific physiological functions.How these distinct biomolecules are differentially sorted through the secretory pathway,however,r
Adipose tissues (ATs) deposit in multiple locations throughout the body such as subcutaneous,visceral and perivascular regions,showing various morphology and physiological functions.