The regulatory effects of Peroxiredoxin Ⅱ on phospholamban phosphorylation and cardiac contractile f

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:HUANming520
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  Peroxiredoxin Ⅱ(prxⅡ),a cytosolic form of the anti-oxidant peroxiredoxin family,was recently found to be decreased in failing human hearts.Interestingly,in hyperdynamic hearts of two genetically modified mouse models with: a)phospholamban ablation; and b)overexpression of the active inhibitor-1 of protein phosphatase 1,the levels of this cellular peroxidase(prxⅡ)were markedly increased.
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