【摘 要】
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a member of transforming growth factor β (TGF-β) family, mostly expressed in skeletal muscles and known to play a crucial role in the negative regulation of muscle growth.Follistatin (FSTN), also know
【机 构】
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Research Center for Laboratory Animal Science of Inner Mongolia University,Hohhot 010070
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a member of transforming growth factor β (TGF-β) family, mostly expressed in skeletal muscles and known to play a crucial role in the negative regulation of muscle growth.Follistatin (FSTN), also known as a suppressor protein of FSH, is a single chain glycoprotein.FSTN can combine with MSTN to block the function of MSTN, and promote muscle growth.MSTN knockout or knockdown and over-expression of FSTN can induce the target animals with significant increase in muscle masses.In this experiment, we constructed interference vectors of MSTN and detected the interference efficiency, and obtained two interference vectors which can disturb the expression of MSTN with high efficiency.
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