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Objective To investigate the association between bone mineral density (BMD) and the haplotype combining estrogen receptor gene Xba Ⅰ,Pvu Ⅱ polymorphisms and osteocalcin gene Hind Ⅲ polymorphism in postmenopausal women.Methods In 307 subjects,the BMD of lumbar spine and hip were measured by dual energy X-ray absorptiometry and the Xba Ⅰ and Pvu Ⅱ polymorphisms of ER gene and the Hind Ⅲ polymorphism of OC gene were genotyped by PCR-RFLP.Results (1) Genotype XX group were signifycantly lower BMD at trochanter than xx genotype group (P<0.05).