炎症反应是宿主重要防御机制之一。慢性炎症或过度炎症反应可导致严重的肺部疾病,如哮喘、急性呼吸窘迫综合征等。新近研究表明炎症消退是一个主动过程,炎症的及时消退是防止炎症过强及走向慢性化的关键环节。因此,调控炎症消退的内源性介质成为新的研究热点。促进炎症消退内源性介质的发现不仅为肺部疾病研究提供新视野,也为全新的促炎症消退治疗策略防治肺部疾病提供理论依据。 Inflammation is one of the important defense mechanisms of the host. Chronic inflammation or excessive inflammation can lead to serious lung diseases such as asthma, acute respiratory distress syndrome and the like. Recent studies have shown that the regression of inflammation is an active process, the timely resolution of inflammation is to prevent the inflammation is too strong and the key to chronic. Therefore, the regulation of endogenous inflammatory mediators has become a new research hotspot. The discovery of endogenous mediators to promote inflammation not only provides a new perspective for the study of lung diseases, but also provides a theoretical basis for the prevention and treatment of lung diseases by a new pro-inflammatory subsided treatment strategy.