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许多非类固醇抗炎药(NSAID)能引起肝毒性。炎痛喜康(piroxicam)除和其它 NSAID 一样具有胃肠道副作用外,尚可引起暂时性转氨酶升高,但停药后即恢复。文献报告该药曾引起严重急性肝炎,并发生死亡。本文报告1例服用炎痛喜康后发生致死性肝亚大块坏死。病例报告 64岁女性,无嗜酒及服用其它毒性药物史。因左髌骨横断性骨折于1987年3月15日手术。住院期间检查肝、肾功能均正常。由于术后疼痛,应用消炎痛100mg/d 共3个月,但无明显缓解,于7月29日改用炎痛喜康40mg/d,服用第5天后,面部发生浮肿,下唇出现荨麻疹皮疹。8月19日出现黄疸、深色尿、恶心和右上腹部不适,不发热,遂停用炎痛喜康。4天后住入外科,检查肝、脾不大,腹部未触及包块。白细胞7 125/mm~3,分类正常,但嗜酸粒细胞
Many non-steroidal anti-inflammatory drugs (NSAIDs) can cause hepatotoxicity. In addition to gastrointestinal side effects like other NSAIDs, piroxicam causes transient transaminases to rise but resumes after withdrawal. The literature reports that the drug caused severe acute hepatitis and died. This article reports a case of fatal hepatomegaly necrosis occurred in 1 case of inflammatory pain. Case report 64-year-old woman, no alcoholism and other toxic drug history. Due to left patellar transverse fracture in March 15, 1987 surgery. Liver and kidney function were normal during hospitalization. Due to postoperative pain, the application of indomethacin 100mg / d for 3 months, but no significant relief on July 29 to Yan Yan Kang 40mg / d, after taking the first 5 days, facial edema, lower urticaria appeared rash. August 19 jaundice, dark urine, nausea and right upper quadrant discomfort, no fever, then stop the inflammatory pain Xikang. Surgical admission after 4 days, check the liver, spleen is not large, the abdomen did not touch the mass. WBC 7 125 / mm ~ 3, normal classification, but eosinophils