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本文利用ELISA法检测了45侧慢性乙型肝炎病人血清抗—HBcIgM。其中29例血清抗—HBCIgM阳性患者的SGPT和血清胆红素水平显著高于16例血清抗—HBcIgM阴性的病人(P<0.01)。血清抗—HBcIgM与血清HBV—DNA的检测有较好的符合率(68.9％)。提示血清抗—HBcIgM与HBV的复制、肝脏病变的炎症活动有关。一般认为,在机体针对某一外来抗原的体液免疫应答中,首先产生IgM型抗体,继之代以IgG型抗体。早期,有人认为检测血清中针对乙型肝炎病毒(HBV)核心抗原的IgM型抗体(抗—HBc IgM)可用于急性乙型肝炎的诊断。但是,有学者认为抗—HBcIgM并非急性乙型肝炎病人所特有,在慢性乙型肝炎病人中也可存在。Surrenti认为,慢性乙型肝炎病人血清抗—HBcIgM与肝脏炎症程度和血清HBeAg均无关系。但Banninger和Kigosawa则认为血清抗—HBcIgM与疾病炎症程度显著相关。本文旨在进一步阐慢性乙型肝脏病人血清抗—HBcIgM明与HBV的复制及肝脏炎症程度的关系。
In this paper, the ELISA method was used to detect serum anti-HBcIgM in 45 patients with chronic hepatitis B. The serum levels of SGPT and serum bilirubin in 29 anti-HBC IgG positive patients were significantly higher than those in 16 anti-HBc IgM negative patients (P <0.01). Serum anti-HBcIgM and serum HBV-DNA detection has a good coincidence rate (68.9%). Tip serum anti-HBcIgM and HBV replication, liver lesions related to inflammatory activity. Is generally believed that the body against a foreign antigen humoral immune response, the first generation of IgM-type antibodies, followed by the generation of IgG-type antibodies. In the early days, IgM antibodies (anti-HBc IgM) against the core antigen of Hepatitis B virus (HBV) in serum tested were considered as being useful in the diagnosis of acute hepatitis B. However, some scholars believe that anti-HBcIgM is not unique to patients with acute hepatitis B, chronic hepatitis B patients may also exist. Surrenti believes that serum anti-HBcIgM in patients with chronic hepatitis B is not related to the degree of liver inflammation and serum HBeAg. However, Banninger and Kigosawa concluded that serum anti-HBcIgM was significantly associated with the degree of inflammation in the disease. The purpose of this article is to further elucidate the relationship between anti-HBc IgM seroprevalence and HBV replication and hepatic inflammation in patients with chronic hepatitis B.