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观察使用磁共振(MRI)导航的高强度聚焦超声(MRgHIFU)消融靠近山羊门静脉的肝组织的病理变化;在MRI监控下,对50只山羊靠近门静脉0、5和10 mm处的肝组织进行热消融。其中40只山羊术后立即处死,另外10只在消融7 d后处死。病理观察显示靶区肝组织完全坏死,治疗后即刻0 mm组门静脉出现胶原纤维肿胀(CS)27/40(67.5%)例,血管壁断裂(VWF)为7/40(17.5%)例;5 mm组门静脉CS为8/40(20%)例,VWF(0/40,0%),两组间CS和VWF发生率差异有显著性(P<0.05);10 mm组未见CS(0/40,0%)和VWF(0/40,0%)。消融后7d,各组门静脉标本在光镜下均未见CS和VWF。以上结果表明,MRgHIFU在距山羊门静脉0~5 mm处消融肝组织可能会造成门静脉的急性损伤,但这种损伤是可逆的。
To observe the pathological changes of liver tissue adjacent to the goat portal vein using MRgHIFU guided by magnetic resonance imaging (MRI); under the MRI monitoring, 50 goats were heated at 0, 5 and 10 mm in the portal vein Ablation. Forty goats were sacrificed immediately after surgery, and the other 10 were sacrificed 7 days after ablation. Pathological observation showed complete necrosis of the liver tissue in the target area. 27.0 (67.5%) cases of collagen fibers swollen (CS) and 7/40 (17.5%) cases of vascular wall rupture (VWF) appeared in 0 mm portal vein immediately after treatment. (P <0.05). There was no significant difference in the incidence of CS and VWF between the two groups (P <0.05) / 40,0%) and VWF (0 / 40,0%). Seven days after ablation, there was no CS and VWF in the portal vein specimens of each group under light microscope. The above results show that MRgHIFU may cause acute portal vein injury at 0.5mm away from the portal vein of goats, but this injury is reversible.