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目的 :探讨原发性高血压患者血清胰岛素样生长因子Ⅱ (IGFⅡ )和肾上腺髓质素 (ADM)变化及其临床意义。方法 :用放射免疫分析测定了 6 2例原发性高血压 (EH)患者和 4 0例非高血压患者的血清IGFⅡ和ADM水平 ,并进行对照统计分析。结果 :EH组血清IGFⅡ和ADM水平均显著高于对照组 (p <0 0 1) ,相互间呈显著正相关 (p <0 0 5 ) ,且均与平均动脉压成显著正相关 (p<0 0 5 ) ,与体重指数无相关性意义。在Ⅰ、Ⅱ、Ⅲ期组间 ,血清ADM水平依次递增 (方差F检验 ,p <0 0 5 ) ,且Ⅲ期组显著高于Ⅰ期组 (p <0 0 1) ,伴心脑肾并发症组血清ADM水平也显著高于无并发症组 (p <0 0 5 ) ;血清IGFⅡ水平则无统计学意义。结论 :EH患者血清IGFⅡ和ADM水平显著升高 ,相互间成正相关 ,且均与平均动脉压成正相关 ,随着病情进展 ,ADM有进一步升高趋势 ,但IGFⅡ则否
Objective: To investigate the changes of serum insulin-like growth factor Ⅱ (IGF Ⅱ) and adrenomedullin (ADM) in patients with essential hypertension and its clinical significance. Methods: Serum levels of IGFⅡ and ADM in 62 patients with essential hypertension (EH) and 40 non-hypertensive patients were measured by radioimmunoassay and compared with the control. Results: Serum levels of IGFⅡ and ADM in EH group were significantly higher than those in control group (p <0.01), and were positively correlated with each other (p <0.05), and were positively correlated with mean arterial pressure (p < 0 0 5), no correlation with body mass index. The levels of serum ADM increased gradually (Ⅰ, Ⅱ, Ⅲ, p <0 05) in stage Ⅰ, Ⅱ and Ⅲ, and were significantly higher in stage Ⅲ than those in stage Ⅰ (p <0.01) Serum ADM levels were also significantly higher in the disease group than in the non-complication group (p <0.05), but not in the serum IGF-II level. CONCLUSIONS: Serum levels of IGFⅡ and ADM in patients with EH are significantly increased, positively correlated with mean arterial pressure, and positively correlated with mean arterial pressure. As the disease progresses, ADM is further increased, but IGFⅡ is not