奥美拉唑(Omeprazole)为1982年瑞典 Astra医药公司首先创制推出的 H~+-K~+-ATP 酶抑制剂,有明显抑制胃壁细胞分泌酸的作用。作为抗消化性溃疡药已在临床广泛应用。其不良反应仅偶见头痛、腹泻、便秘、恶心、皮疹等.引起心电图类似下壁心肌梗死改变,至今未见报道。我近期于临床遇1例报道如下。患者女性,67岁,因贲门腺癌切除术后一个月, Omeprazole was the first H ~ + -K ~ + -ATPase inhibitor invented by Astra Pharmaceutical Co., Ltd. in 1982 in Sweden. It obviously inhibited the secretion of acid in gastric parietal cells. As anti-peptic ulcer drugs have been widely used in clinical. Adverse reactions only occasionally see headache, diarrhea, constipation, nausea, rash, etc .. ECG caused a similar change of inferior myocardial infarction, has not been reported. I recently reported a clinical case as follows. Female patient, 67 years old, one month after cardiac adenocarcinoma resection,