AIM:To investigate the association of nuclear morphometryand DNA content with resectability of pancreatic cancer.METHODS:A total of 36 patients with pancreaticadenocarcinoma were divided into resectable group andunresectable group.The nuclear morphometry and DNAcontents of tumor cells were analyzed by IBAS autoimagineanalyzer from paraffin-embedded materials.Localization size,histological type and grade,and clinical stage of the tumorwere evaluated.Factors influencing resectability of pancreaticcancer were investigated using stepwise regression analysis.RESULTS:Statistical significance was found in nuclear DNAcontent(integrated optical density,IOD)of tumor cells(1.64±0.41 vs 2.96±0.55),DNA ploidy,ages(46.5±5.3 yearsvs 58.6±0.7 years)and tumor volumes(298.1±101.5 cm~3 vs634.7±512.5 cm~3)in both groups(P<0.05),and no differencewas found in the nuclear morphometry(P>0.05).The ratesof diploid/tetraploid and aneuploid were 66.7 % and 33.3% in resectable group respectively,and 38.9 % and 62.1%in unresectable group,respectively(P<0.05).IOD(X_(12)),ploidystatus(X_(13))and clinical stage(X_3)were radical resectableindicators with statistical significance.The regression equationfor resectability was Y=-9.2053+3.5428X_(12)+2.5390X_(13)-2.3001X_3(RR=0.8780,P<0.01).CONCLUSION: There is a high correlation between resectability of pancreatic cancers and their DNA contents, DNA ploidy status and clinical stage. AIM: To investigate the association of nuclear morphometry and DNA content with resectability of pancreatic cancer. METHODS: A total of 36 patients with pancreaticadenocarcinoma were divided into resectable group and unsectable group. Nuclear morphometry and DNAcontents of tumor cells were analyzed by IBAS autoimagineanalyzer from paraffin- embedded materials. Localization size, histological type and grade, and clinical stage of the tumorwere evaluated. Factors influencing resectability of pancreatic cancer were investigated using stepwise regression analysis. RESULTS: Statistical significance was found in nuclear DNA content (integrated optical density, IOD) of tumor cells (1.64 ± 0.41 vs 2.96 ± 0.55), DNA ploidy, ages (46.5 ± 5.3 years vs 58.6 ± 0.7 years) and tumor volumes (298.1 ± 101.5 cm -3 vs 634.7 ± 512.5 cm -3) in both groups ), and no difference was found in the nuclear morphometry (P> 0.05). The rates of diploid / tetraploid and aneuploid were 66.7% and 33.3% in resectable group respectively, and 38.9% a nd 62.1% in unresectable group, respectively (P <0.05) .IOD (X_ (12)), ploidystatus (X_ (13)) and clinical stage (X_3) were radical resectableindicators with statistical significance.The regression equationfor resectability was Y = 9.2053 + 3.5428X_ (12) + 2.5390X_ (13) -2.3001X_3 (RR = 0.8780, P <0.01) .CONCLUSION: There is a high correlation between resectability of pancreatic cancers and their DNA contents, DNA ploidy status and clinical stage.