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疟疾是世界上最广泛流行的寄生虫病之一,由于氯喹毒性低而疗效高,是当前治疗疟疾的首选的化疗药物,它无致畸性,故可在孕期安全使用,但也有报告氯喹可引起子宫收缩增强,为此,作者等研究了氯喹的催产作用。研究采用实验室繁殖的、未产的 Wister 大鼠,每天光照12小时。将动情前期雌大鼠与有生育力的雄鼠合笼后每天作阴道涂片,以阴道发现精子为孕第一天,于孕18天时在轻度麻醉下切除双侧卵巢,由于卵巢来源的孕酮突然降低,引起宫内胎鼠死亡和吸收。另取一组孕鼠,于孕18天时同样作双侧卵
Malaria is one of the most widespread parasitic diseases in the world. It is the first choice of chemotherapeutic drugs currently used in the treatment of malaria due to its low chloroquine toxicity and its high efficacy. It is safe to use during pregnancy but chloroquine is also reported Causing uterine contractions to enhance, for which, the author studied the oxychlorination of oxytocin. Study using laboratory breeding, unproduced Wister rats, 12 hours of light per day. The pre-estrus female rats and fertile male cages daily vaginal smear, vaginal sperm were found for the first day of pregnancy, 18 days of pregnancy under mild anesthesia under the excision of both ovaries, ovary-derived Progesterone suddenly decreased, causing intrauterine fetal death and absorption. Another set of pregnant rats, the same 18-day pregnant eggs for both sides