目的:该文以温岭市为例,首次报道中国中学女生继发性闭经的发病原因及治疗效果。方法:以2006-2010年在浙江省温岭市第一医院就诊妇科疾病的12至19岁女中学生为研究对象,通过详细询问病史、雌激素水平、孕激素水平、垂体促性腺激素水平、影像学检查及腔镜检查,确认患者发病原因,统计继发性患者人数及不同类型病因患者人数,对患者治疗9个月后观察治疗效果。结果:通过诊断确诊继发性闭经女生131人,占统计期间内就诊女生人数的8.22%。其中下丘脑性闭经占93.1%(122/131),卵巢性闭经占1.5%,药物性闭经占3.8%,子宫性闭经和其他原因引起的闭经各占0.8%。下丘脑性闭经治疗有效率为97.5%,其余各组闭经经治疗后均治愈。结论:下丘脑功能异常导致的继发性闭经是温岭市中学女生继发性闭经最主要的类型,绝大多数女中学生经治疗后可以恢复正常月经。 Aim: This paper reports the causes and the therapeutic effects of secondary amenorrhea in Chinese high school girls for the first time, taking Wenling City as an example. Methods: A total of 12-19-year-old female middle school students with gynecological diseases in the First Hospital of Wenling, Zhejiang Province from 2006 to 2010 were selected as study subjects. By detailed history, estrogen level, progesterone level, pituitary gonadotropin level, Examination and endoscopy to confirm the cause of the disease, statistics of the number of secondary patients and the number of different types of patients, the treatment of patients after 9 months to observe the therapeutic effect. Results: 131 cases of secondary amenorrhea girls diagnosed by diagnosis, accounting for 8.22% of the number of girls attending the survey. Hypothalamic amenorrhea accounted for 93.1% (122/131), ovarian amenorrhea accounted for 1.5%, drug-induced amenorrhea accounted for 3.8%, uterine amenorrhea and other causes of amenorrhea caused by 0.8%. The efficacy of hypothalamic amenorrhea treatment was 97.5%, and the rest of the groups were cured after treatment. Conclusion: Secondary amenorrhea caused by hypothalamic dysfunction is the most important type of secondary amenorrhea in high school girls in Wenling. Most female secondary school students can resume normal menstruation after treatment.