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目的:研究MTS1/p16基因在人肺癌组织中的变化。方法:应用Southern杂交分析了46例肺癌组织标本,PCR技术分析89例肺癌组织标本。结果:Southern杂交检测p16基因的缺失率为17.4％(8/46),PCR检测p16基因缺失率为25.8％(23/89)。结论:MTS1/p16基因缺失在肺癌发生发展中可能起重要作用
Objective: To study the changes of MTS1 / p16 gene in human lung cancer. Methods: Southern blot analysis of 46 cases of lung cancer specimens, PCR analysis of 89 cases of lung cancer specimens. Results: The deletion rate of p16 gene was 17.4% (8/46) detected by Southern blotting, and the deletion rate of p16 gene was 25.8% (23/89) by PCR. Conclusion: MTS1 / p16 gene deletion may play an important role in the development of lung cancer