慢性阻塞性肺疾病(COPD)合并侵袭性肺曲霉菌病(IPA)的发病率呈逐年上升趋势,而糖皮质激素的应用、广谱抗生素治疗、高龄、低蛋白血症、贫血、糖尿病、支气管扩张等基础病及机械通气的使用均是该病的危险因素。而COPD合并IPA临床表现及影像学改变均缺乏特异性,因此就需要呼吸科医师对该病有充分的认识,在治疗过程中观察患者症状、体征变化,及时送痰培养、行肺部CT检查等,尽早做出临床诊断或拟诊,及早开始抗真菌治疗才是改善患者预后的关键,降低病死率。 The incidence of chronic obstructive pulmonary disease (COPD) complicated with invasive pulmonary aspergillosis (IPA) has been increasing year by year, and glucocorticoid use, broad-spectrum antibiotic treatment, advanced age, hypoproteinemia, anemia, diabetes, bronchial Dilatation and other basic diseases and the use of mechanical ventilation are risk factors for the disease. The COPD with IPA clinical manifestations and imaging changes are lack of specificity, so you need to have a thorough understanding of the disease respiratory disease physicians in the treatment of patients with symptoms and signs of change, and timely sputum culture, lung CT examination As soon as possible to make a clinical diagnosis or diagnosis, early antifungal therapy is the key to improving the prognosis of patients and reduce mortality.