The rotating packed bed (RPB) has been widely used in gas-liquid flow systems as a process intensifica-tion device,exhibiting excellent mass transfer enhancement characteristics.However,the complex inter-nal structure and the high-speed rotation of the rotor in RPB bring significant challenges to study the intensification mechanism by experiment methods.In the past two decades,Computational fluid dynam-ics (CFD) has been gradually applied to simulate the hydrodynamics and mass transfer characteristics in RPB and instruct the reactor design.This article covers the development of the CFD simulation of gas-liquid flow in RPB.Firstly,the improvement of the simulation method in the aspect of mathematical mod-els,geometric models,and solving methods is introduced.Secondly,new progress of CFD simulation about hydrodynamic and mass transfer characteristics in RPB is reviewed,including pressure drop,veloc-ity distribution,flow pattern,and concentration distribution,etc.Some new phenomena such as the end effect area with the maximum turbulent have been revealed by this works.In addition,the exploration of developing new reactor structures by CFD simulation is introduced and it is proved that such new struc-tures are competitive to different applications.The defects of current research and future development directions are also discussed at last.