Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobuli

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：zphym

【摘要】

：

Mutation of mevalonate kinase(MVK) is thought to account for most cases of hyperimmunoglobulinemia D syndrome(HIDS) with recurrent fever.However,its mechanism a

【作者】

：

WANG Ping WEI ZhiGuo YAN BoWen

【机构】

：

CollegeofBiologicalSciences,CollegeofAnimalScience＆Technology

【出处】

：

中国科学：生命科学英文版

【发表日期】

：

2012年3期

【关键词】

：

转基因小鼠模型血清免疫球蛋白分泌型特异性表达肝脏 SOUTHERN杂交反转录PCR HIDS sIgD liver-specific express

【基金项目】

：

This work was supported by the National Basic Research Program of China （Grant No. 2010CB945300）.

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Mutation of mevalonate kinase(MVK) is thought to account for most cases of hyperimmunoglobulinemia D syndrome(HIDS) with recurrent fever.However,its mechanism and the relationship between elevated serum immunoglobulin D(IgD) and the clinical features of H

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Establishment of a transgenic mouse model with liver-specific expression of secretory immunoglobuli

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