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已知体重减轻相关性闭经与中枢鸦片能系活性改变有关。为评价长效鸦片能受体阻断剂纳曲酮治疗体重相关性下丘脑闭经的效果及与快速纳洛酮试验LH反应有无相关性,选择40例体重指数(BMI)<20的下丘脑性闭经患者,按对快速纳洛酮试验LH反应程度分成3组:A组无反应15例,给予两周期HRT(E_2贴片100μg/次,每周两次,共24天,末13天加安宫黄体酮10mg/d,停药7天为1周期)后再重复纳洛酮试验。然后开始纳曲酮治疗:剂量25mg/d,
It is known that weight loss-related amenorrhea is associated with altered activity of the central opiogenic system. To evaluate the effect of naltrexone, a long-acting opioid receptor blocker, on weight-related hypothalamic amenorrhea and whether there is a correlation with fast naloxone test LH response, 40 hypothalamic patients with body mass index (BMI) <20 were selected Amenorrhea patients, according to rapid naloxone LH test response were divided into three groups: A group of 15 cases without response, giving two cycles of HRT (E2 E_2 patch 100μg / twice a week for a total of 24 days, the end of 13 days plus Andong progesterone 10mg / d, withdrawal for 7 days for a cycle) and then repeat the naloxone test. Then start naltrexone treatment: a dose of 25mg / d,