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目的探讨老年慢性支气管炎（老慢支）患者外周血Ｔ细胞亚群和血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）的变化及意义。方法采用抗体致敏的红细胞花环法测定外周血Ｔ细胞亚群，用双抗体夹心法测定血清ｓＩＬ－２Ｒ。结果老慢支患者Ｔ细胞亚群ＣＤ４明显减少，ＣＤ８明显增多，ＣＤ４／ＣＤ８比值降低，与对照组比较均有显著性意义（Ｐ＜０．００１），而ｓＩＬ－２Ｒ水平较对照组显著增高（Ｐ＜０．００１），且与Ｔ细胞亚群ＣＤ４、ＣＤ４／ＣＤ８成负相关，与ＣＤ８成正相关，尤其以急性发作期改变最为显著。结论老慢支病程中出现某些不同程度的免疫调节紊乱，同时，本研究揭示Ｔ细胞亚群和ｓＩＬ－２Ｒ的改变可作为老慢支患者病情变化和预后判断的指标之一。
Objective To investigate the changes of peripheral blood T lymphocyte subsets and serum soluble interleukin-2 receptor (sIL-2R) in elderly patients with chronic bronchitis (chronic bronchitis) and its clinical significance. Methods Peripheral blood T lymphocyte subsets were determined by antibody-sensitized erythrocyte rosette and serum sIL-2R was measured by double antibody sandwich method. Results Compared with the control group, CD4 + CD8 and CD4 (superscript +) CD8 of the patients with chronic bronchitis and chronic bronchitis were significantly decreased (P <0.001), while the level of sIL-2R was significantly higher than that of the control group (P <0.001), and it was negatively correlated with T cell subsets CD4, CD4 / CD8, positively correlated with CD8, especially in acute exacerbation. Conclusions There are some different degrees of immunoregulatory disorders in the course of chronic bronchitis. In the meantime, this study reveals that the changes of T cell subsets and sIL-2R may be one of the indicators of the prognosis and prognosis of patients with chronic bronchitis.