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胃动素(motilin,MTL)是一种胃肠道激素,与胃肠动力学以及肿瘤的发生治疗有密切的关系。近年来有关MTL与各种疾病的研究已有报道。但未见有关MTL与癌症手术期变化规律的研究,作者采用放射免疫分析法(RIA)对38例住院食管癌与21例贲门癌患者进行了术前、术后不同手术期的血浆MTL的含量检测,并同时以45例健康献血员作正常对照组。结果表明,食管贲门癌患者均具有高胃动素血症。由于肿瘤组织的影响导致胃肠生理改变且促使MTL显著升高的重要因素。MTL在食管贲门癌不同手术期的变化与MTL受体敏感性减退以及手术刺激引起的神经系统改变和神经体液调节有关。
Motilin (MTL) is a gastrointestinal hormone that has a close relationship with gastrointestinal motility and the occurrence and treatment of tumors. In recent years, studies on MTL and various diseases have been reported. However, there was no study on the variability of MTL and cancer operative period. The authors used radioimmunoassay (RIA) to perform the preoperative and postoperative perioperative MTL plasma MTL levels in 38 patients with inpatient esophageal cancer and 21 patients with cardiac cancer. Assays and 45 healthy blood donors served as normal controls at the same time. The results showed that patients with esophageal and cardiac cancer had hypermotilinemia. Changes in the gastrointestinal physiology due to the effects of tumour tissue and important factors contributing to a significant increase in MTL. MTL changes in different operative stages of esophageal and cardiac cancer are associated with decreased sensitivity of MTL receptors and neurological changes and neurohumoral regulation caused by surgical stimulation.