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对100例男性慢性嗜酒者进行血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL－C）、低密度脂蛋白胆固醇（LDL－C）、载脂蛋白A-I（APOAI）、我脂蛋白-B（APOB）6项指标检测，并对其中28例中、大量饮酒者改为小量或药物治疗3～6个月后跟踪监测上述6项指标，结果表明：中、大量饮酒者血中TC、TG、LDL－C、APOB升高（P＜0．01），HDL－C、APOAI水平降低（P＜0．01）；小量饮酒者血中HDL－C、APOAI水平增高（P＜0．01），TC、TG、LDL－C、APOB无明显改变（P＞0．05）。因此，过量饮酒是脑血管病（CVD）的重要危险因素。
The serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein AI APOAI), and my lipoprotein-B (APOB). Six of the 28 patients, a large number of drinkers were changed to small amount or 3 to 6 months after drug treatment. The above six indicators were followed up and monitored. The results showed that: (P <0.01), while HDL-C and APOAI levels decreased (P <0.01) in the heavy drinkers; HDL-C, APOAI level increased (P <0.01), TC, TG, LDL-C and APOB had no significant changes (P> 0.05). Therefore, excessive alcohol consumption is an important risk factor for cerebrovascular disease (CVD).