本文的目的为观察免疫抑制剂(硫唑嘌呤)对严重慢性活动性肺结节病,且经长期皮质激素治疗无效病例的治疗作用。观察了10例(男性6例,女性4例)经组织学证实的慢性肺结节病,皮质激素长期治疗无效并符合第Ⅸ届结节病国际会议所订病变活动性的标准。治疗方案为硫唑嘌呤150mg/日,连续治疗6个月。疗效判断根据治疗前、后所作临床血清和肺泡液的免疫—生物学检查。生物学检查包括:血清—血管紧张素转换酶 The purpose of this article is to investigate the therapeutic effect of an immunosuppressant (azathioprine) on severe chronic active pulmonary sarcoidosis and ineffective treatment with long-term corticosteroids. 10 cases (6 males and 4 females) were observed histologically confirmed chronic pulmonary sarcoidosis, long-term treatment of corticosteroids ineffective and in line with the IX session of the International Conference on Sarcomatoid lesions set activity standards. Treatment regimen is azathioprine 150mg / day, continuous treatment for 6 months. Efficacy judgments based on the clinical serum and alveolar fluid before immunotherapy - biological examination. Biological tests include: serum-angiotensin-converting enzyme