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目的分析白血病相关性基因(LRP16)、增殖细胞核抗原(K-67,Ki67)及表皮生长因子受体-1(EGFR)在乳腺癌组织中的表达,并探讨其表达与乳腺癌的临床病理因素及预后的关系。方法运用免疫组化的方法检测86例乳腺癌患者组织中LRP16、Ki67及EGFR的表达,并分析其与临床病理因素的相关性及预后的关系。结果 LRP16、Ki67及EGFR在乳腺癌组织中的阳性表达率分别为52.3%、70.9%、16.3%,不同年龄组的各项指标表达均无统计学差异(P>0.05)。LRP16表达与临床分期、组织分级、肿瘤大小、淋巴结转移、呈相关性(P<0.05);Ki67表达与临床分期、组织分级、肿瘤大小、淋巴结转移呈相关性(P<0.05);EGFR表达与组织分级呈相关性(P<0.05)。LRP16阳性组与阴性组术后局部复发和转移时间相比较有统计学意义(P<0.05);Ki67阳性组与阴性组术后局部复发和转移时间相比较亦有统计学意义(P<0.05);而EGFR阳性组与阴性组术后局部复发和转移时间相比较无统计学意义(P>0.05)。结论联合检测乳腺癌组织中LPR16、Ki67、EGFR表达情况,能更清楚地了解乳腺癌的生物学行为,可为患者的诊断、治疗及预后评估提供重要的临床指导意义。
Objective To analyze the expression of LRP16, K-67, Ki67 and EGFR in breast cancer and to investigate the relationship between the expression of LRP16 and clinicopathological factors And prognosis. Methods The expressions of LRP16, Ki67 and EGFR in 86 cases of breast cancer tissues were detected by immunohistochemistry. The correlations with the clinicopathological parameters and prognosis were analyzed. Results The positive expression rates of LRP16, Ki67 and EGFR in breast cancer tissues were 52.3%, 70.9% and 16.3%, respectively. There was no significant difference in the expression of various indexes between different age groups (P> 0.05). The expression of LRP16 was correlated with clinical stage, histological grade, tumor size and lymph node metastasis (P <0.05). Ki67 expression was correlated with clinical stage, histological grade, tumor size and lymph node metastasis (P <0.05) Tissue grading was correlated (P <0.05). There were significant differences in the local recurrence and metastasis time between LRP16-positive group and negative group (P <0.05). The Ki67-positive group and negative group also had statistically significant difference in the time of local recurrence and metastasis (P <0.05) ; While EGFR positive group and negative group postoperative local recurrence and metastasis time was not statistically significant (P> 0.05). Conclusions Combined detection of LPR16, Ki67 and EGFR expression in breast cancer can provide a better understanding of the biological behavior of breast cancer and provide an important clinical guideline for the diagnosis, treatment and prognosis evaluation of patients.