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重度植物神经功能紊乱性直立性低血压在老年中并不少见,大多数患者无特殊病因,治疗结果也不理想。多巴胺β化酶(DBH)缺乏的主要症状就是体位性低血压,实验室检查特点是血浆中肾上腺素或去甲肾上腺素含量偏低甚至无法捡出,而血浆多巴胺含量偏高且易查出。该酶可催化多巴胺转化成去甲肾上腺素。文献上曾报道过6例DBH缺乏的年轻患者,但至今尚未对老年重度体位性低血压提出是DBH缺乏的假设。本文首次报道一83岁高龄老年
Severe autonomic dysfunction in orthostatic hypotension is not uncommon in the elderly, most patients with no specific cause, the treatment results are not satisfactory. The main symptom of dopamine β-enzyme (DBH) deficiency is orthostatic hypotension. Laboratory tests are characterized by low or even low levels of epinephrine or norepinephrine in the plasma, whereas plasma dopamine is highly detectable. This enzyme catalyzes the conversion of dopamine to norepinephrine. Six young patients with DBH deficiency have been reported in the literature, but so far no hypothesis of DBH deficiency has been proposed for severe elderly orthostatic hypotension. This article first covers a 83-year-old senior citizen