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Angiotensin Ⅱ(AngⅡ)plays an important role in the pathogenesis of hypertension and associated renal injuries.To elucidate the molecular mechanism by which AngⅡ induces renal damage,we found that AngⅡ infusion significantly induced CYP4A14 expression in renal proximal tubule cells(RPTCs)with marked increases in blood pressure and proteinuria.